2004/9 - 2008/7，中國(guó)科學(xué)技術(shù)大學(xué)，生物技術(shù)，學(xué)士
2008/9 - 2013/6，中國(guó)科學(xué)院大學(xué)，生物化學(xué)與分子生物學(xué)，博士
2013/7 – 2016/12，中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院，助理研究員
2017/1 –2022/12，中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院，副研究員
2023/1 – 至今，中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院，研究員
基于糖脂代謝和蛋白翻譯后修飾的多能干細(xì)胞命運(yùn)轉(zhuǎn)換的機(jī)制研究
1，國(guó)家自然科學(xué)基金-優(yōu)秀青年項(xiàng)目
2，中國(guó)科學(xué)院青年創(chuàng)新促進(jìn)會(huì)優(yōu)秀會(huì)員
3，廣州市科學(xué)技術(shù)局基礎(chǔ)研究計(jì)劃
4，國(guó)家自然科學(xué)基金-青年項(xiàng)目
5，廣東省公益研究與能力建設(shè)項(xiàng)目
6，廣東省自然科學(xué)基金-博士啟動(dòng)項(xiàng)目
Fundamental Research雜志第一屆青年編委
2023年度國(guó)家自然科學(xué)基金優(yōu)秀青年
2021年度中國(guó)科學(xué)院青年創(chuàng)新促進(jìn)會(huì)優(yōu)秀會(huì)員
2020年度廣東省自然科學(xué)一等獎(jiǎng)（5/15）
2017年度中國(guó)科學(xué)院杰出科技成就獎(jiǎng)（主要完成者）
1. Guangsuo Xing, Zichao Liu, Luyuan Huang, … Duanqing Pei*, Xingguo Liu*, Keshi Chen*. MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening, Cell Death & Differentiation, 2022, 29(5):1042-1054
2. Yi Wu#, Keshi Chen#, Linpeng Li#, Zhihong Hao#, …Xingguo Liu*. Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation, Cell Death & Differentiation, 2022, 29(11):2316-2331
3. Linpeng Li#, Keshi Chen#, Tianyu Wang#, Yi Wu#, …Xingguo Liu*. Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism, 2020, 2(9): 882-892
4．Keshi Chen; Qi Long; Guangsuo Xing; …Duanqing Pei *; Xingguo Liu *, Heterochromatin loosening by Oct4 linker facilitates Klf4’s binding and initiates iPSC reprogramming. EMBO Journal, 2020, 39(1):e99165
5. Yi Wu #; Keshi Chen#; Guangsuo Xing; …Xingguo Liu*, Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. Science Advances, 2019, 5(11):eaax7525
6. Linpeng Li#, Keshi Chen#, Yi Wu, …Xingguo Liu*. Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction, Cell Death & Disease, 2017,?8(10):e3107,
7. Keshi Chen#, Qi Long#, Tao Wang, …Xingguo Liu*, Duanqing Pei*. Gadd45a is a heterochramatin relaxer that enhances iPS cell generation, EMBO Reports, 2016, 17(11):1641-1656
8.Yi Wu#, Keshi Chen#, Xiyin Liu, …Xingguo Liu*. Srebp-1 interacts with c-Myc to enhance somatic cell reprogramming, Stem Cells, 2016, 34(1):83-92
9. Danyun Zhao, Yi Wu, Keshi Chen*. Tbx3 isofroms are involved in pluripotency maintaining through distinct regulation of Nanog transcriptional activity, Biochem Biophys Res Commun, 2014, 444(3):411-414
10. Linpeng Li#, Keshi Chen#, Yi Wu#, …Xingguo Liu*. Epigenome-Metabolome-Epigenome signaling cascade in cell biological processes, Journal of Genetics and Genomics, 2022, 49(4):279-286
