唐士兵博士主要運(yùn)用藥物化學(xué)和化學(xué)生物學(xué)等學(xué)科的技術(shù)手段發(fā)現(xiàn)活性分子并將其應(yīng)用于化學(xué)生物學(xué)基礎(chǔ)研究和創(chuàng)新藥物發(fā)現(xiàn)，特別是針對(duì)惡性腫瘤和代謝性疾病等疾病的新型靶標(biāo)進(jìn)行新分子實(shí)體發(fā)現(xiàn)和臨床前研究。

研究方向包括：1）惡性腫瘤、代謝性疾病等疾病的藥物研發(fā)；2）生物活性工具分子的設(shè)計(jì)合成和應(yīng)用研究；3）小分子藥物的合成策略和工藝優(yōu)化；

01. Liu X,?Zhang Y,?Chu Y,?Zhao X,?Mao L,?Zhao S,?Lin S,?Hui X,?Gu P,?Xu Y, Loomes K, Tang S^*, Nie T^*, Wu D^*.?The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis.?Biochem Biophys Res Commun. 2021;545:189-194. PMID: 33561654

02. Tan J, Liu H, Huang M, Li N, Tang S, Meng J, Tang S, Zhou H, Kijlstra A, Yang P, Hou S. Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation. Cell Death Dis.?2020 Aug 22;11(8):697. PMID: 32829384

03. Zhao S, Chu Y, Zhang Y, Zhou Y, Jiang Z, Wang Z, Mao L, Li K, Sun W, Li P, Jia S, Wang C, Xu A, Loomes K, Tang S, Wu D, Hui X, Nie T.Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation. Life Sci.?2019 Apr 1;222:117-124. PMID: 30708100

04. Sun W,?Zhao X,?Wang Z,?Chu Y,?Mao L,?Lin S,?Gao X,?Song Y,?Hui X,?Jia S,?Tang S,?Xu Y,?Xu A,?Loomes K,?Wang C,?Wu D,?Nie T. Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway. Mol Metab.?2019 Oct;28:48-57. PMID: 31352005

05. Hou L^#, Yang G^#, Tang S^#, Alcazar C, Joshi P, Strassberg Z, Kim M, Kawamura M, Woo YJ, Shrager J, Ding S, Huang NF. A small molecule derived from carboxyethylpyrrole protein adducts promotes angiogenesis in a mouse model of peripheral arterial disease. J Am Heart Assoc.?2018 Sep 18;7(18):e009234. PMID: 30371212

06. Qin Y^#, Tang S^#, Zhen G, Ding Q, Ding S, Cao X. Bone-targeted delivery of TGF-β type 1 receptor inhibitor rescues uncoupled bone remodeling in Camurati-Engelmann disease. Ann N Y Acad Sci.?2018 Dec; 1433(1):29-40. PMID: 30091466

07. Yang B^#, Tang S^#, Ma C^#, Li ST, Kobayashi T, Hoppmann C, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L. Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions. Nat Commun.?2017 Dec 21;8(1):2240. PMID: 29269770

08. Xie M^#, Tang S^#, Li K, Ding S. Pharmacological reprogramming of somatic cells for regenerative medicine. Acc Chem Res. 2017 May 16; 50(5):1202-1211. PMID: 28453285.

09. Mohamed TMA, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang Y, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D. Chemical enhancement of in vitro and in vivo direct cardiac reprogramming. Circulation. 2017 Mar 7; 135(10):978-995. PMID: 27834668. (Reported by a number of major media reports, including ABC 7, Fierce Biotech, Daily Mail, etc.)

10. Nie B, Nie T, Hui X, Gu P, Mao L, Li K, Yuan R, Zheng J, Wang H, Li K, Tang S, Zhang Y, Xu T, Xu A, Wu D, Ding S. Brown adipogenic reprogramming induced by a small molecule. Cell Rep.2017 Jan 17;18(3):624-635. PMID: 28099842.

11. Nakamura PA, Shimchuk AA, Tang S, Wang Z, Degolier K, Ding S, Reh TA. Small molecule Photoregulin3 prevents retinal degeneration in the Rho^P23H mouse model of Retinitis Pigmentosa. eLife 2017 Nov 17; 6. pii: e30577. PMID: 29148976.

12. Nakamura PA, Tang S, Shimchuk AA, Ding S, Reh TA. Potential of small molecule-mediated reprogramming of rod photoreceptors to treat retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2016 Nov 1; 57(14):6407-6415. PMID: 27893103. (Reported by Foundation Fighting Blindness)

13. Tang S^#, Xie M^#, Cao N, Ding S. Patient-specific induced pluripotent stem cells for disease modeling and phenotypic drug discovery. J Med Chem. 2016 Jan 14; 59(1):2-15. PMID: 26322868.

14. Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S. Human pancreatic beta-like cells converted from fibroblasts. Nat Commun. 2016 Jan 6; 7:10080. PMID: 26733021. (Reported by a number of major media reports, including Fox News, The Independent, SF Business Times,etc.)