朱強(qiáng)實(shí)驗(yàn)室網(wǎng)頁(yè)?
研究經(jīng)歷: ?
2008年5月 至今 中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院 PI，研究員 ?
2005年9月 至 2008年2月 美國(guó)公司 XTL Biopharmaceuticals Inc. staff scientist ?
2001年4月 至 2005年9月 美國(guó)公司 Vivoquest, Inc. staff scientist?
2000年8月 至 2001年4月美國(guó)科羅拉多州立大學(xué)化學(xué)系博士后?
??
教育背景：?
1995年9月 至 2000年6月 中國(guó)科學(xué)院上海有機(jī)化學(xué)研究所博士學(xué)位?
1991年9月 至 1995年6月 南京大學(xué)化學(xué)化工學(xué)院本科學(xué)位?
?。?）C？H鍵官能化反應(yīng)用于雜環(huán)化合物合成方法研究；?
?。?）Cu/O2 體系對(duì)有機(jī)小分子的選擇性氧化；?
?。?）異腈參與的新反應(yīng)研究；?
?。?）藥物分子合成工藝的改進(jìn)；?
?。?）抗肺癌，抗肺結(jié)核藥物開(kāi)發(fā)。?
1．國(guó)家自然科學(xué)基金科學(xué)部主任基金（20942001）“異腈參與的多取代喹啉的合成研究”，2009年1月至2009年12月，8萬(wàn)元，主持，已結(jié)題。
2．廣州市科技計(jì)劃項(xiàng)目（2010Y1-C241）“以鄰炔基苯胺為原料合成幾類重要的含氮雜環(huán)”，2011年1月至2011年12月，6萬(wàn)元，主持，已結(jié)題。
3．國(guó)家自然科學(xué)基金面上項(xiàng)目（21072190）“通過(guò)分子內(nèi)C-H鍵官能化合成幾類雜環(huán)化合物的新方法研究”，2011年1月至2013年12月，36萬(wàn)元，主持，已結(jié)題。
4. 2011年廣東省自然科學(xué)基金重點(diǎn)項(xiàng)目(S2011020000806)“銅/氧氣體系催化的烯烴脫氫氧胺化反應(yīng)極其應(yīng)用研究”，2011年1月至2013年12月，30萬(wàn)元，主持，已結(jié)題。
5.中國(guó)科學(xué)院（人才項(xiàng)目）2011年1月至2013年12月，200萬(wàn)元，主持，已結(jié)題。
6. 國(guó)家自然科學(xué)基金面上項(xiàng)目(21272233)“高價(jià)碘試劑催化的氧化環(huán)化反應(yīng)研究”, 2013年至2016年, 80萬(wàn)元，主持，已結(jié)題。
7．國(guó)家自然科學(xué)基金青年基金(21202167) “銅/氧氣體系催化的烯烴脫氫氧胺化反應(yīng)研究” 2013年至2015年，25萬(wàn)元，課題組成員黃金波博士主持，已結(jié)題。
8. 廣東省自然科學(xué)基金(2014A030313796) 2015年至2017年，10萬(wàn)元，課題組成員黃金波博士主持，已結(jié)題。
9. 中國(guó)科學(xué)院青年創(chuàng)新促進(jìn)會(huì)（人才項(xiàng)目） 2015年至2018年，60萬(wàn)元，課題組成員羅爽博士主持，在研。
10. 國(guó)家自然科學(xué)基金面上項(xiàng)目(21472190)“鈀催化的亞胺基化環(huán)化反應(yīng)用于構(gòu)建雜環(huán)化合物的研究”, 2015年至2018年, 95萬(wàn)元，主持，在研。
11．國(guó)家自然科學(xué)基金青年基金(21402203) “過(guò)渡金屬催化的雙碳?xì)滏I的羰基化反應(yīng)” 2015年至2017年，25萬(wàn)元，課題組成員羅爽博士主持，已結(jié)題。
12. 國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目項(xiàng)目(21532009)“過(guò)渡金屬催化烯烴的氧化官能化新反應(yīng)研究”, 2016年至2020年, 180 萬(wàn)元，參與，在研。(上海有機(jī)化學(xué)研究所劉國(guó)生研究員主持，總經(jīng)費(fèi)380萬(wàn)元)
13. 國(guó)家自然科學(xué)基金面上項(xiàng)目(21672215)“吲哚-2-酮-3-螺噻嗪酮類化合物的抗結(jié)核活性研究”, 2017年至2020年, 65萬(wàn)元，課題組成員黃金波博士主持，在研。
14．國(guó)家自然科學(xué)基金面上項(xiàng)目(21772198)“鈀催化的不對(duì)稱亞胺基化反應(yīng)研究”, 2018年至2021年, 64萬(wàn)元，課題組成員羅爽博士主持，在研。
1998年，上海有機(jī)化學(xué)研究所首屆劉鑄晉獎(jiǎng)?
2012年，中科院廣州教育基地優(yōu)秀研究生導(dǎo)師?
2012年，中科院優(yōu)秀研究生導(dǎo)師獎(jiǎng)?
2018年
59. Cascade double isocyanide insertion and C–N coupling of 2-iodo-2′-isocyano-1,1′-biphenyls
Hongwei Sun, Shi Tang, Dengke Li, Yali Zhou, Jinbo Huang* and Qiang Zhu*
Org. Biomol. Chem. 2018, 16, 3893-3896. Impact factor: 3.423
58. PhI(OAc)2-Mediated Dearomative C–N Coupling: Facile Construction of the Spiro[indoline-3,2’-pyrrolidine] Skeleton
Yali Zhou, Dengke Li, Shi Tang, Hongwei Sun, Jinbo Huang* and Qiang Zhu*
Org. Biomol. Chem. 2018, 16, 2039-2042. Impact factor: 3.423
????????
57. Pd-Catalzed Divergent C(sp2)–H Activation/Cycloimidlylation of 2-Isocyano-2,3-diarylpropanoates
Shi Tang, Sheng-Wen Yang, Hongwei Sun, Yali Zhou, Juan Li* and Qiang Zhu*
Org. Lett. 2018, 20, 1832-1836. Impact factor:6.492
56. Enantioselective Synthesis of Planar Chiral Pyridoferrocenes via
Palladium-Catalyzed Imidoylative Cyclization Reactions
Shuang Luo,* Zhuang Xiong, Yongzhi Lu and Qiang Zhu*
Org. Lett. 2018, 20, 1837-1840. Impact factor:6.492
55. Stirring-Controlled Mono or Double Aminocarbonylation of 1,3-Bis(2-
iodoaryl)propan-2-amines
Huaanzi Hu, Zeqiang Xie, Shuang Luo* and Qiang Zhu*
Tetrahedron Lett. 2018, 59, 1034-1037. Impact factor:2.125
2017年
54. Palladium-Catalyzed Imidoylative Cyclization of Tryptophan-Derived Isocyanides: Access to β-Carbolines
Shi Tang, Jian Wang, Zhuang Xiong, Zeqiang Xie, Dengke Li, Jinbo Huang* and Qiang Zhu*
Org. Lett. 2017, 19, 5577-5580. Impact factor:6.492.
53. Palladium-Catalyzed C(sp2)–H Aminoimidoylation of Isocyano-Containing Arenes: Synthesis of Amino Substituted N-Heterocycles
Zhuang Xiong, Jian Wang, Yanbo Wang, Shuang Luo* and Qiang Zhu*
Org. Chem. Front. 2017, 4, 1768-1771. Impact factor:5.455
52. Copper-Catalyzed Regioselective 1,2-Thioamidation of Alkenes
Dengke Li, Tingting Mao, Jinbo Huang and Qiang Zhu*
Chem. Commun. 2017, 53, 3450-3453. Impact factor: 6.290
51. A One-Pot Synthesis of [1,2,3]Triazolo[1,5-a]quinoxalines from 1-Azido-2-isocyanoarenes with High Bond-Forming E?ciency
Dengke Li, Tingting Mao, Jinbo Huang and Qiang Zhu*
Chem. Commun. 2017, 53, 1305-1308. Impact factor: 6.290
50. Palladium-Catalyzed Enantioselective C(sp2)–H lmidoylation by Desymmetrization
Jian Wang, De-Wei Gao, Jinbo Huang, Shi Tang, Zhuang Xiong, Huaanzi Hu, Shu-Li You* and Qiang Zhu*
ACS Catal. 2017, 7, 3832-3836. Impact factor:11.384
49. Denitrogenative Imidoyl Radical Cyclization: Synthesis of 2 Substituted Benzoimidazoles from 1 Azido-2-isocyanoarenes
Dengke Li, Tingting Mao, Jinbo Huang and Qiang Zhu*
Org. Lett. 2017, 19, 3223-3226. Impact factor:6.492
2016年
48. Imidoylative Heck Reaction: Synthesis of Cyclic Ketoimines from Functionalized Isocyanide
Jian Wang, Shi Tang and Qiang Zhu*
Org. Lett. 2016, 18, 3074-3077.
47. Transition Metal-Free Amidoalkylation of Benzothiazoles and
Amidoalkylarylation of Activated Alkenes with N,N-Dialkylamides
Jian Wang, Jing Li, Jinbo Huang* and Qiang Zhu*
J. Org. Chem. 2016, 81, 3017-3022.
46. Pd-Catalyzed C(sp2)–H Carbonylation of 2-Benzylpyridines for the Synthesis of Pyridoisoquinolinones
Zeqiang Xie, Shuang Luo* and Qiang Zhu*
Chem. Commun. 2016, 52, 12873-12876.
45. A Metal-Free Synthesis of 2-Aminobenzothiazoles through Aminyl Radical Addition to Arylisothiocyanates
Yimiao He, Jing Li, Shuang Luo, Jinbo Huang* and Qiang Zhu*
Chem. Commun. 2016, 52, 8444-8447.
44. Copper-Mediated C(sp3)–H Azidation with Me3SiN3: Synthesis of Imidazoles from Ketones and Aldehydes
Zeqiang Xie, Jiaojiao Deng, Zhiping Qiu, Juan Li* and Qiang Zhu*
Chem. Commun. 2016, 52, 6467-6470.
43. Dearomative C–C and C–N Bond Cleavage of 2-Arylindoles: Transition-Metal-Free Access to 2-Aminoarylphenones
Shuang Luo,* Ziwei Hu and Qiang Zhu*
Org. Chem. Front. 2016, 3, 364-367.
42. Copper-Mediated C(sp3)–H Amination in a Multiple C–N Bond-Forming Strategy for the Synthesis of N-heterocycles
Zeqiang Xie, Jiangling Peng and Qiang Zhu*
Org. Chem. Front. 2016, 3, 82-86.
41. Recent Progress in Imydoyl Radical-Involved Reactions
Jian Lei, Jinbo Huang and Qiang Zhu*
Org. Biomol. Chem. 2016, 14, 2593-2602.
2015年
40. Palladium-Catalyzed Intramolecular C(sp2)–H Imidoylation for the Synthesis of Six-Membered N-Heterocycles
Jing Li, Yimiao He, Shuang Luo, Jian Lei, Jian Wang, Zeqiang Xie and Qiang Zhu*
J. Org. Chem. 2015, 80, 2223-2230.
39. A Facile Synthesis of Pyrazoles through Metal-Free Oxidative C(sp2)–H Cycloamination of Vinyl Hydrazones
Dongdong Liang and Qiang Zhu*
Asian J. Org. Chem. 2014, 4, 42-45.
38. Copper-Catalyzed Tri?uoromethylalkynylation of Isocyanides
Jian Lei, Xiaoxing Wu* and Qiang Zhu*
Org. Lett. 2015, 17, 2322-2325.
37. Copper-Catalyzed Trifluoromethylation of Trisubstituted Allylic and Homoallylic Alcohols
Jian Lei, Xiaowu Liu, Shaolin Zhang, Shuang Jiang, Minhao Huang, Xiaoxing Wu* and Qiang Zhu*
Chem. Eur. J. 2015, 21, 6700-6703.
36. Aminopalladation-Triggered Carbene Insertion Reaction: Synthesis of 2-(1H-Indol-3-yl)acetates
Ziwei Hu, Shuang Luo* and Qiang Zhu*
Adv. Synth. Catal. 2015, 357, 1060-1064.
35. Palladium-Catalyzed Intermolecular C–H Amidation of Indoles with Sulfonyl Azides
Ziwei Hu, Shuang Luo* and Qiang Zhu*
Sci. China. Chem. 2015, 58, 1349-1353.
34. Surface Con?ned Retro Diels-Alder Reaction Driven by the Swelling of Weak Polyelectrolytes
Beier Lyu, Wenli Cha, Tingting Mao, Yuanzi Wu, Hujun Qian, Qiang Zhu* and Hongwei Ma*
ACS Appl. Mater. Interfaces 2015, 7, 6254-6259.
2014年
33. Arylative Cyclization of 2-Isocyanobiphenyls with Anilines: One-Pot Synthesis of 6-Arylphenanthridines via Competitive Reaction Pathways
Zhonghua Xia, Jinbo Huang, Yimiao He, Jiaji Zhao, Jian Lei and Qiang Zhu*
Org. Lett. 2014, 16, 2546-2549.
32. Palladium-Catalyzed C(sp2)–H Pyridocarbonylation of N-Aryl-2-aminopyridines: Dual Function of the Pyridyl Moiety
Dongdong Liang, Yimiao He and Qiang Zhu*
Org. Lett. 2014, 16, 2748-2751.
31. Palladium-Catalyzed Imidoylative Cyclization of α-Isocyanoacetamides: Efficient Access to C2-Diversified Oxazoles
Jian Wang, Shuang Luo, Jinbo Huang, Tingting Mao and Qiang Zhu*
Chem. Eur. J. 2014, 20, 11220-11224.
30. Copper-Mediated C(sp2)–H Amination Using TMSN3 as a Nitrogen Source: Redox-Neutral Access to Primary Anilines
Jiangling Peng, Ming Chen, Zeqiang Xie, Shuang Luo and Qiang Zhu*
Org. Chem. Front. 2014, 1, 777-781.
29. Copper-Catalyzed C(sp2)–H Amidation with Azides as Amino Sources
Jiangling Peng, Zeqiang Xie, Ming Chen, Jian Wang and Qiang Zhu*
Org. Lett. 2014, 16, 4702-4705.
28. A Room-Temperature Synthesis of 2,2’-Bisoxazoles through Palladium-Catalyzed Oxidative Coupling of α-Isocyanoacetamides
Jian Wang, Shuang Luo, Jing Li and Qiang Zhu*
Org. Chem. Front. 2014, 1, 1285-1288.
27. Copper-Catalyzed Intramolecular Oxidative C(sp3)–H Amidation of 2-Amino- acetophenones: Efficient Synthesis of Indoline-2,3-diones
Jinbo Huang*, Tingting Mao and Qiang Zhu*
Eur. J. Org. Chem. 2014, 2878-2882.
2013年
26. Synthesis of Phenanthridinones via Palladium-Catalyzed C(sp2)–H Aminocarbonylation of Unprotected o-Arylanilines
Dongdong Liang, Ziwei Hu, Jiangling Peng, Jinbo Huang and Qiang Zhu*
Chem. Commun. 2013, 49, 173-175.
25. Synthesis of 10-Methylacridin-9(10H)-ones through Cu-Catalyzed Intramolecular Oxidative C(sp2)–H Amination of o-N-Methylaminobenzophenones
Jinbo Huang, Congqing Wan, Ming-Fang Xu* and Qiang Zhu*
Eur. J. Org. Chem. 2013, 1876-1880.
24. C–H Cycloamination of N-Aryl-2-aminopyridines and N-Arylamidines Catalyzed by an in situ Generated Hypervalent Iodine(III) Reagent
Yimiao He, Jinbo Huang, Dongdong Liang, Lanying Liu and Qiang Zhu*
Chem. Commun. 2013, 49, 7352-7354.
23. A Metal-Free Tandem Demethylenation/C(sp2)–H Cycloamination Process of N?Benzyl-2-aminopyridines via C–C and C–N Bond Cleavage
Dongdong Liang, Yimiao He, Lanying Liu and Qiang Zhu*
Org. Lett. 2013, 15, 3476-3479.
22. A Transition-Metal-Free Synthesis of Arylcarboxyamides from Aryl Diazonium Salts and Isocyanides
Zhonghua Xia and Qiang Zhu*
Org. Lett. 2013, 15, 4110-4113.
21. Synthesis of 1H-Indole-3-carboxamidines through a Palladium-Catalyzed Three-Component Reaction Involving Isocyanide Insertion as a Key Step
Ziwei Hu, Jian Wang, Dongdong Liang and Qiang Zhu*
Adv. Synth. Catal. 2013, 355, 3290-3294.
2012 年
20. Direct Carboxamidation of Indoles by Palladium-Catalyzed C–H Activation and Isocyanide Insertion
Jiangling Peng, Lanying Liu, Ziwei Hu, Jinbo Huang and Qiang Zhu*
Chem. Commun. 2012, 48, 3772-3774.
19. Cu-Catalyzed Oxidative C(sp2)–H Cycloetherification of o-Arylphenols for the Preparation of Dibenzofurans
Jiaji Zhao, Yong Wang, Yimiao He, Lanying Liu, Qiang Zhu*
Org. Lett. 2012, 14, 1078-1081.
18. Cu-Catalyzed Regioselective C–H Aerobic Oxidative Cycloetherification of o-Arylphenols Bearing an Additional Directing Group
Jiaji Zhao, Yong Wang and Qiang Zhu*
Synthesis 2012, 44, 1551-1555.
17. Palladium(II)-Catalyzed Cycloamidination via C(sp2)–H Activation and Isocyanide Insertion
Yong Wang and Qiang Zhu*
Adv. Synth. Catal. 2012, 354, 1902-1908.
16. Palladium-Catalyzed Cyclization of o-Alkynyltrifluoroacetanilides Followed by Isocyanide Insertion: Synthesis of 2-Substituted 1H-Indole-3-carboxamides
Ziwei Hu, Dongdong Liang, Jiaji Zhao, Jinbo Huang and Qiang Zhu*
Chem. Commun. 2012, 48, 7371-7373.
15. Palladium-Catalyzed C(sp2)–H Cyanation Using Tertiary Amine Derived Isocyanide as a Cyano Source
Jiangling Peng, Jiaji Zhao, Ziwei Hu, Dongdong Liang, Jinbo Huang and Qiang Zhu*
Org. Lett. 2012, 14, 4966-4969.
14. CuI-Mediated Sequential Iodination/Cycloetherification of o-Arylphenols: Synthesis of 2- or 4-Iododibenzofurans and Mechanistic Studies
Jiaji Zhao, Qi Zhang, Lanying Liu, Yimiao He, Jing Li, Juan Li* and Qiang Zhu*
Org. Lett. 2012, 14, 5362-5365.
13. Synthesis of Benzimidazoles by PIDA-Promoted Direct C(sp2)–H Imidation of N-Arylamidines
Jinbo Huang, Yimiao He, Yong Wang and Qiang Zhu*
Chem. Eur. J. 2012, 18, 13964-13967.
2011 年
12. Palladium-Catalyzed Intramolecular C(sp2)–H Amidination by Isonitrile Insertion Provides Direct Access to 4-Aminoquinazolines from N-Arylamidines
Yong Wang, Honggen Wang, Jiangling Peng and Qiang Zhu*
Org. Lett. 2011, 13, 4604-4607.
11. Bronsted Acid-Promoted Sequential Hydroarylation-Hydroamidation of Arene Tethered 1-(2-Alkynylphenyl)ureas: Direct Access to 4,4-Spiro-3,4-dihydro-2-(1H)- quinazolinones
Honggen Wang, Jiaji Zhao, Jiancun Zhang* and Qiang Zhu*
Adv. Synth. Catal. 2011, 353, 2653-2658.
10. Sequential Hydration-Condensation-Double Cyclization of Pyridine-Substituted 2-Alkynylanilines: an Efficient Approach to Quinoline-Based Heterocycles
Lijie Peng, Honggen Wang, Changlan Peng, Ke Ding* and Qiang Zhu*
Synthesis 2011, 1723-1732.
9. Synthesis of Quinazolin-4(3H)-ones via Pd(II)-Catalyzed Intramolecular C(sp2)–H Carboxamidation of N-Arylamidines
Bin Ma, Yong Wang, Jiangling Peng and Qiang Zhu*
J. Org. Chem. 2011, 76, 6362-6366.
8. Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl-Substituted Aromatic N-Heterocycles
Honggen Wang, Yong Wang, Dongdong Liang, Lanying Liu, Jiancun Zhang* and Qiang Zhu*
Angew. Chem., Int. Ed. 2011, 50, 5678-5681.
2010 年
7. Synthesis of 2-Alkoxy(aroxy)-3-substituted Quinolines by DABCO-Promoted Cyclization of ortho-Alkynylaryl Isocyanides
Jiaji Zhao, Changlan Peng, Lanying Liu, Yong Wang and Qiang Zhu*
J. Org. Chem. 2010, 75, 7502-7504.
6. A Direct Intramolecular C–H Amination Reaction Co-Catalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines
Honggen Wang, Yong Wang, Changlan Peng, Jiancun Zhang* and Qiang Zhu*
J. Am. Chem. Soc. 2010, 132, 13217-13219.
5. p-Toluenesulfonic Acid Promoted Annulation of 2-Alkynylanilines with Activated Ketones: Efficient Synthesis of 4-Alkyl-2,3-Disubstituted Quinolines
Changlan Peng, Yong Wang, Lanying Liu, Honggen Wang, Jiaji Zhao and Qiang Zhu*
Eur. J. Org. Chem. 2010, 818-822.
4. Structure-Based Design, Synthesis and Biological Evaluation of New N-Carboxyphenylpyrrole Derivatives as HIV Fusion Inhibitors Targeting gp41
Yong Wang, Hong Lu, Qiang Zhu*, Shibo Jiang* and Yun Liao*
Bioorg. Med. Chem. Lett. 2010, 20, 189-192.
2009 年
3. An Efficient Synthesis of 4-Alkyl-2(1H)-quinazolinones and 4-Alkyl-2-chloroquinazolines from 1-(2-Alkynylphenyl)ureas
Honggen Wang, Lanying Liu, Yong Wang, Changlan Peng, Jiancun Zhang* and Qiang Zhu*
Tetrahedron Lett. 2009, 50, 6841-6843.
2. Tetrabutylammonium Chloride-Triggered 6-endo Cyclization of o-Alkynylisocyanobenzenes: an Efficient Synthesis of 2-Chloro-3-Substituted Quinolines
Lanying Liu, Yong Wang, Honggen Wang, Changlan Peng, Jiaji Zhao and Qiang Zhu*
Tetrahedron Lett. 2009, 50, 6715-6719.
1. Sulfuric Acid Promoted Condensation Cyclization of 2-(2-(Trimethylsilyl)ethynyl)anilines with Arylaldehydes in Alcoholic Solvents: an Efficient One-Pot Synthesis of 4-Alkoxy-2-arylquinolines
Yong Wang, Changlan Peng, Lanying Liu, Jiaji Zhao, Li Su and Qiang Zhu*
Tetrahedron Lett. 2009, 50, 2261-2265.
專利：
1. 吳東海, 朱強(qiáng), 楊松, 劉蘭英, 彭長(zhǎng)蘭
青蒿素衍生物的新應(yīng)用，ZL201010216620.0
2. 朱強(qiáng), 王洪根, 王勇, 梁冬冬, 劉蘭英, 張健存
咪唑[1,2-a]吡啶和咪唑醛類化合物的新合成方法, 專利號(hào)：201110110748.3
3. 朱強(qiáng), 張?zhí)煊? 劉蘭英, 魯明輝, 毛婷婷，黃金波
吲哚[3,2-c]喹啉類化合物或其藥學(xué)上可接受的鹽及其制備方法和應(yīng)用, 中國(guó)專利號(hào)：201310385431.X
4. 涂正超，朱強(qiáng)，張?zhí)煊睿S金波，徐曉冰，萬(wàn)軍庭，黎敏科，李登科，周亞麗，劉志永，王邦興，米琦.托特雷拉
吲哚-2-酮-3-螺噻嗪或噻唑酮化合物及其應(yīng)用，中國(guó)專利號(hào)：CN201610657161.7
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