2004-9至2009-6,?河北農(nóng)業(yè)大學(xué),?學(xué)士

2010-9至2013-6,?北京林業(yè)大學(xué),?碩士

2013-9至2017-8,?中國科學(xué)院廣州生物醫(yī)藥與健康研究院,?助理研究員

2017-9至2020-6,?中國科學(xué)院大學(xué),?博士

2020-7至2022-7,?生物島實(shí)驗(yàn)室,??副研究員

2022-8至今,?中國科學(xué)院廣州生物醫(yī)藥與健康研究院,??副研究員

早期胚胎發(fā)育過程中的細(xì)胞命運(yùn)與決定

表觀遺傳學(xué)變化的機(jī)制研究

國家自然科學(xué)基金青年基金???? （1項(xiàng)/主持）

廣州市基礎(chǔ)與應(yīng)用基礎(chǔ)研究項(xiàng)目 （1項(xiàng)/主持）

國家重點(diǎn)研發(fā)計(jì)劃???????????? （1項(xiàng)/項(xiàng)目骨干）

1.?????? Chen J, Liang L, Li Y, Zhang Y, Zhang M, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Law PY, Loh HH, Pei D, Sun H#, Zheng H#. Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway. FASEB J. 2020 Apr;34(4):5917-5930. doi: 10.1096/fj.201902873R. Epub 2020 Mar 10. PMID: 32154623. 共同通訊作者

2.?????? Sun H, Yang X, Liang L, Zhang M, Li Y, Chen J, Wang F, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Lin L, Pei D, Zheng H. Metabolic switch and epithelial-mesenchymal transition cooperate to regulate pluripotency. EMBO J. 2020 Apr 15;39(8):e102961. doi: 10.15252/embj.2019102961. Epub 2020 Feb 24. PMID: 32090361; PMCID: PMC7156961.

3.?????? He S, Wang F, Zhang Y, Chen J, Liang L, Li Y, Zhang M, Yang X, Pang H, Li Y, Huang X, Qin D, Pei D, Sun H, Zheng H. Hemi-methylated CpG sites connect?Dnmt1-knockdown-induced and?Tet1-induced DNA demethylation during somatic cell reprogramming. Cell Discov. 2019 Feb 12;5:11. doi: 10.1038/s41421-018-0074-6. PMID: 30774978; PMCID: PMC6370818. 共同通訊作者

4.?????? He S, Sun H, Lin L, Zhang Y, Chen J, Liang L, Li Y, Zhang M, Yang X, Wang X, Wang F, Zhu F, Chen J, Pei D, Zheng H. Passive DNA demethylation preferentially up-regulates pluripotency-related genes and facilitates the generation of induced pluripotent stem cells. J Biol Chem. 2017 Nov 10;292(45):18542-18555. doi: 10.1074/jbc.M117.810457. Epub 2017 Sep 18. PMID: 28924038; PMCID: PMC5682964.共同第一作者

5.?????? Sun H, Liang L, Li Y, Feng C, Li L, Zhang Y, He S, Pei D, Guo Y, Zheng H. Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch. Sci Rep. 2016 Aug 2;6:30903. doi: 10.1038/srep30903. PMID: 27481483; PMCID: PMC4969595.

6.?????? Liang L, Sun H, Zhang W, Zhang M, Yang X, Kuang R, Zheng H. Meta-Analysis of EMT Datasets Reveals Different Types of EMT. PLoS One. 2016 Jun 3;11(6):e0156839. doi: 10.1371/journal.pone.0156839. PMID: 27258544; PMCID: PMC4892621. 共同第一作者

7.?????? Zou Y, Zhang J, Xu J, Fu L, Xu Y, Wang X, Li Z, Zhu L, Sun H, Zheng H, Guo J. SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages. Cell Biosci. 2021 Dec 14;11(1):210. doi: 10.1186/s13578-021-00725-y. PMID: 34906231; PMCID: PMC8672560.

8.?????? Liu J, Li L, Zou Y, Fu L, Ma X, Zhang H, Xu Y, Xu J, Zhang J, Li M, Hu X, Li Z, Wang X, Sun H, Zheng H, Zhu L, Guo J. Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury. Neural Regen Res. 2022 Mar;17(3):673-681. doi: 10.4103/1673-5374.320997. PMID: 34380909; PMCID: PMC8504388.

9.?????? Zhang M, Li Q, Yang T, Meng F, Lai X, Liang L, Li C, Sun H, Sun J, Zheng H. Positive feedback between retinoic acid and 2-phospho-L-ascorbic acid trisodium salt during somatic cell reprogramming. Cell Regen. 2020 Oct 1;9(1):17. doi: 10.1186/s13619-020-00057-1. PMID: 33000315; PMCID: PMC7527398.

10.??? Meng F, Li Y, Sun H, Li C, Li Q, Law PY, Loh HH, Liang L, Zheng H. Naloxone Facilitates Contextual Learning and Memory in a Receptor-Independent and Tet1-Dependent Manner. Cell Mol Neurobiol. 2021 Jul;41(5):1031-1038. doi: 10.1007/s10571-020-00970-8. Epub 2020 Sep 28. PMID: 32989585.

11.??? Liang L, Chen J, Li Y, Lai X, Sun H, Li C, Zhang M, Yang T, Meng F, Law PY, Loh HH, Zheng H. Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway. Cell Rep. 2020 Mar 17;30(11):3625-3631.e6. doi: 10.1016/j.celrep.2020.02.075. PMID: 32187535.

12.??? Lin L, Liang L, Yang X, Sun H, Li Y, Pei D, Zheng H. The homeobox transcription factor MSX2 partially mediates the effects of bone morphogenetic protein 4 (BMP4) on somatic cell reprogramming. J Biol Chem. 2018 Sep 21;293(38):14905-14915. doi: 10.1074/jbc.RA118.003913. Epub 2018 Aug 10. PMID: 30097516; PMCID: PMC6153288.

13.??? He S, Chen J, Zhang Y, Zhang M, Yang X, Li Y, Sun H, Lin L, Fan K, Liang L, Feng C, Wang F, Zhang X, Guo Y, Pei D, Zheng H. Sequential EMT-MET induces neuronal conversion through Sox2. Cell Discov. 2017 May 30;3:17017. doi: 10.1038/celldisc.2017.17. PMID: 28580167; PMCID: PMC5450022.

14.??? Huang Z, Liang L, Li L, Xu M, Li X, Sun H, He S, Lin L, Zhang Y, Song Y, Yang M, Luo Y, Loh HH, Law PY, Zheng D, Zheng H. Opioid doses required for pain management in lung cancer patients with different cholesterol levels: negative correlation between opioid doses and cholesterol levels. Lipids Health Dis. 2016 Mar 8;15:47. doi: 10.1186/s12944-016-0212-9. PMID: 26952011; PMCID: PMC4782347.

15.??? He S, Guo Y, Zhang Y, Li Y, Feng C, Li X, Lin L, Guo L, Wang H, Liu C, Zheng Y, Luo C, Liu Q, Wang F, Sun H, Liang L, Li L, Su H, Chen J, Pei D, Zheng H. Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo. Cell Regen. 2015 Dec 30;4:12. doi: 10.1186/s13619-015-0027-6. PMID: 26719791; PMCID: PMC4696146.

16.??? Liu X, Sun H, Qi J, Wang L, He S, Liu J, Feng C, Chen C, Li W, Guo Y, Qin D, Pan G, Chen J, Pei D, Zheng H. Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol. 2013 Jul;15(7):829-38. doi: 10.1038/ncb2765. Epub 2013 May 26. PMID: 23708003.

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專利

1.?????? 鄭輝; 李文; 何松蔚; 孫昊; 納絡(luò)酮用于制備提高空間學(xué)習(xí)記憶能力的藥物中的應(yīng)用, 2016-8-24, 中國, ZL201410393385.2.?