教育經(jīng)歷??????

2008.09—2012.06?河南師范大學(xué)生命科學(xué)學(xué)院，生物科學(xué)專業(yè)學(xué)士

2012.09—2017.12?中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院，細(xì)胞生物學(xué)碩博連讀

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工作經(jīng)歷

2018.01—2020.02??廣州生物院-廣醫(yī)聯(lián)合生科院，博士后

2020.03—2022.12 ?中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院，特別研究助理

2023.01—2024.11??中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院，副研究員

2024.12月至今 ?中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院發(fā)育與再生醫(yī)學(xué)研究中心器官發(fā)育與再生研究組，研究組長(zhǎng)

研究方向?yàn)樵缙谂咛グl(fā)育中的譜系調(diào)控、利用全能性細(xì)胞構(gòu)建類胚胎和功能性組織、利用干細(xì)胞進(jìn)行同種或異種嵌合。首次開發(fā)了全能性人8細(xì)胞樣細(xì)胞誘導(dǎo)體系，并從多組學(xué)層面完整地描繪了誘導(dǎo)過(guò)程中的關(guān)鍵分子事件和基因調(diào)控網(wǎng)絡(luò)；通過(guò)優(yōu)化多能干細(xì)胞培養(yǎng)體系和胚胎嵌合技術(shù)，首次實(shí)現(xiàn)了腎臟發(fā)育缺陷豬體內(nèi)再造人源化中腎組織；首次獲得具有高嵌合率的猴-猴嵌合活體的制備；篩選出調(diào)控人原始態(tài)多能干細(xì)胞分化為人滋養(yǎng)外胚層細(xì)胞的關(guān)鍵因子。以（共）第一或通訊作者在Nature（Nature Methods發(fā)表專評(píng)）、Cell（封面文章，Nature發(fā)表專評(píng)）、Cell Stem Cell（封面文章，Science發(fā)表專評(píng)）、Nature Cell Biology、Nature Communications等高水平雜志發(fā)表相關(guān)成果，相關(guān)成果獲得新華社、人民日?qǐng)?bào)、泰晤士報(bào)、衛(wèi)報(bào)、紐約時(shí)報(bào)等國(guó)內(nèi)外媒體廣泛報(bào)道。

·?Md. Abdul Mazid*^#, Carl Ward^#,?Zhiwei Luo^#, Chuanyu Liu^#, Yunpan Li, Yiwei Lai, Liang Wu, Jinxiu Li, Wenqi Jia, Yu Jiang, Hao Liu, Lixin Fu, Yueli Yang,?David P. Iban?ez, Junjian Lai, Xiaoyu Wei, Juan An, Pengcheng Guo, Yue Yuan, Qiuting Deng, Yang Wang, Ying Liu, Fei Gao, Junwen Wang, Shahriar Zaman,?Baoming Qin, Guangming Wu, Patrick H. Maxwell, Xun Xu, Longqi Liu*, Wenjuan Li*,?Miguel A. Esteban*. Rolling back of human pluripotent stem cells to an 8-cell embryo-like stage.?Nature,?2022?(605): 315-324?(Nature Methods發(fā)表專評(píng)) ?^#第一作者，*通訊作者

·?Yueli Yang^#, Wenqi Jia^#, Zhiwei Luo, Hao Liu, Yunpan Li, David P. Iba?ez, Jinxiu Li, Yu Jiang, Lixin Fu, Junjian Lai, Liang Wu, Yiwei Lai, Longqi Liu, Miguel A. Esteban*, Md Abdul Mazid*, Wenjuan Li*.?VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification. Nature Communications, 2024?15, 583?(編輯選薦) ^#第一作者，*通訊作者

·?Jing Cao^#, Wenjuan Li^#,?Jie Li^#, Md. Abdul Mazid^#, Chunyang Li^#, Yu Jiang^#, Wenqi Jia^#, Zhaodi Liao, Shiyu Sun, Jiqiang Fu, Yan Wang, Yong Lu, Yuting Xu, Yanhong Nie, Xinyan Bian, Changshan Gao, Xiaotong Zhang, Liansheng Zhang, Yunpan Li, Lixin Fu, Hao Liu, Junjian Lai, Yang Wang, Yue Yuan, Yiwei Lai, Longqi Liu, Xiaolong Wang, Qiang Sun*, Miguel A. Esteban*, Zhen Liu*.?Live Birth of Chimeric Macaque Monkey with High Contribution from Homologous Embryonic Stem Cells. Cell, 2023?186(23): 4996-5014?(封面文章，Nature發(fā)表專評(píng)) ^?#第一作者，*通訊作者

·?Jiaowei Wang^#, Wenguang Xie^#, Nan Li^#, Wenjuan Li^#, Zhishuai Zhang^#, Nana Fan, Zhen Ouyang, Yu Zhao, Chengdan Lai, Hao Li, Mengqi Chen, Longquan Quan, Yunpan Li, Yu Jiang, Wenqi Jia, Lixin Fu, Md. Abdul Mazid, Yanling Zhu, Patrick H. Maxwell, Guangjin Pan*, Miguel A. Esteban*, Zhen Dai*, Liangxue Lai*. Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation. Cell Stem Cell, 2023?30(9): 1235-1245 (封面文章，Science發(fā)表專評(píng)) ?^#第一作者，*通訊作者

·?Qiang Zhuang^#, Wenjuan Li^#,?Christina Benda^#, Zhijian Huang, Tanveer Ahmed, Ping Liu, Xiangpeng Guo, David P Iba?ez, Zhiwei Luo, Meng Zhang, Mazid Md Abdul, Zhongzhou Yang, Jiayin Yang, Yinghua Huang, Hui Zhang, Dehao Huang, Jianguo Zhou, Xiaofen Zhong, Xihua Zhu, Xiuling Fu, Wenxia Fan, Yulin Liu, Yan Xu, Carl Ward, Muhammad Jadoon Khan, Shahzina Kanwal, Bushra Mirza, Micky D Tortorella, Hung-Fat Tse, Jiayu Chen, Baoming Qin, Xichen Bao, Shaorong Gao, Andrew P. Hutchins*, Miguel A. Esteban*.?NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming. Nature Cell Biology, 2018?20(4): 400-412 ^#第一作者，*通訊作者

·?Yunpan Li,?David P. Ibanez, Wenxia Fan, Ping Zhao, Shuhan Chen, Mazid Md. Abdul, Yu Jiang, Lixin Fu, Zhiwei Luo, Zhenhua Liu, Yueli Yang, Jifeng Guo, Giacomo Volpe, Shahzina Kanwal, Dongye Wang, Beisha Tang*, Wenjuan Li*.?Generation of an induced pluripotent stem cell line (GIBHi004-A) from a Parkinson's disease patient with mutant DJ-1/PARK7 (p.L10P). Stem Cell Research, 2020?46: 101845. ^#第一作者，*通訊作者

·?Zhiwei Luo,?Xiaobing Qing,?Christina Benda,?Zhijian Huang, Meng Zhang,?Yinghua Huang, Hui Zhang, Lulu Wang, Yiwei Lai, Carl Ward, Giacomo Volpe, Xiaofen Zhong, Baoming Qin, Qiang Zhuang**, Miguel A. Esteban*, Wenjuan Li*.?Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming. Cell Regeneration, 2019?8(1):21-29. ^#第一作者，*通訊作者

·?Jiayi Wei^#, Yueyang Sun^#, Heming Wang^#, Tong Zhu^#, Li Li^#, Ying Zhou, Quan Liu, Zhen Dai, Wenjuan Li, Taihua Yang, Bingmei Wang, Changfeng Zhu, Xizhong Shen, Qunyan Yao, Guangqi Song, Yicheng Zhao and Hao Pei. Designer cellular spheroids with DNA origami for drug screening. Science Advances, 2024 (10), eado9880 ^#第一作者，*通訊作者

·?Jinxiu Li^#, Lixin Fu^#, Yunpan Li^#, Wei Sun, Yao Yi, Wenqi Jia, Haiwei Li, Hao Liu, Pengcheng Guo, Yang Wang, Yue Shen, Xiuqing Zhang, Yuan Lv, Baoming Qin, Wenjuan Li, Chuanyu Liu, Longqi Liu, Md. Abdul Mazid, Yiwei Lai, Miguel A. Esteban, Yu Jiang* and Liang Wu*. A single-cell chromatin accessibility dataset of human primed and nai?ve pluripotent stem cell-derived teratoma. Scientific Data, 2024, 11:725 ^#第一作者，*通訊作者

·?Jie Li^#, Qingyuan Zhu^#, Jing Cao^#, Ying Liu^#, Yong Lu^#, Yining Sun, Qian Li, Yiming Huang, Shenshen Shang, Xinyan Bian, Chunyang Li, Liansheng Zhang, Yan Wang, Yanhong Nie, Jiqiang Fu, Wenjuan Li,?Md. Abdul Mazid, Yu Jiang, Wenqi Jia, Xiaolong Wang, Yidi Sun, Miguel A. Esteban, Qiang Sun*, Fan Zhou* and Zhen Liu*. Cynomolgus monkey embryo model captures gastrulation and early pregnancy. Cell Stem Cell, 2023 (30), 362–377.^??#第一作者，*通訊作者

·?Li Chen, Qiaoqiao Tong, Xiaowen Chen, Penglei Jiang, Hua Yu, Qianbing Zhao, Lingang Sun, Chao Liu, Bin Gu, Yuping Zheng, Lijiang Fei, Xiao Jiang, Wenjuan Li, Giacomo Volpe, Mazid MD. Abdul, Guoji Guo, Jin Zhang, Pengxu Qian, Qiming Sun, Dante Neculai, Miguel A. Esteban, Chen Li, Feiqiu Wen and Junfeng Ji. PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus.?Nature Communications, 2021, 12(1). ^#第一作者，*通訊作者

·?Isaac A. Babarinde, Gang Ma, Yuhao Li, Boping Deng, Zhiwei Luo, Hao Liu, Mazid Md. Abdul, Carl Ward, Minchun Chen, Xiuling Fu, Liyang Shi, Martha Duttlinger, Jiangping He, Li Sun, Wenjuan Li, Qiang Zhuang, Guoqing Tong, Jon Frampton, Jean-Baptiste Cazier, Jiekai Chen, Ralf Jauch, Miguel A. Esteban and Andrew P. Hutchins. Transposable element sequence fragments incorporated into coding and noncoding transcripts modulate the transcriptome of human pluripotent stem cells. Nucleic Acids Research, 2021, 49(16). ^#第一作者，*通訊作者

·?Meng Zhang^#, Yiwei Lai^#, Vladislav Krupalnik^#, Pengcheng Guo, Xiangpeng Guo, Jianguo Zhou, Yan Xu, Zhijun Yu, Longqi Liu, Ao Jiang, Wenjuan Li, Mazid Md. Abdul, Gang Ma, Na Li, Xiuling Fu, Yuan Lv, Mengling Jiang, Muqddas Tariq, Shahzina Kanwal, Hao Liu, Xueting Xu, Hui Zhang, Yinghua Huang, Lulu Wang, Shuhan Chen, Isaac A. Babarinde, Zhiwei Luo, Dongye Wang, Tiantian Zhou, Carl Ward, Minghui He, David P. Iban?ez, Yunpan Li, Jiajian Zhou, Jie Yuan, Yayan Feng, Karthik Arumugam, Umberto Di Vicino, Xichen Bao, Guangming Wu,?Axel Schambach, Huating Wang, Hao Sun, Fei Gao, Baoming Qin, Andrew P. Hutchins, Bradley W. Doble, Christine Hartmann, Maria Pia Cosma, Yan Qin, Guo-Liang Xu, Runsheng Chen, Giacomo Volpe, Liang Chen*, Jacob H. Hanna* and Miguel A. Esteban*. β-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus. Science Advances, 2020, 6(29). ^#第一作者，*通訊作者

·?Meng Zhang, David P. Iba?ez, Wenxia Fan, Hao Liu, Xiaofen Zhong, Xiwei Wang, Yingying Li, Mazid Md. Abdul, Wenjuan Li, Yunpan Li, Carl Ward, Shuhan Chen, Dongye Wang, Baoming Qin, Miguel A. Esteban, Ping Zhao, Zhiwei Luo. Generation of a PARK2 homozygous knockout induced pluripotent stem cell line (GIBHi002-A-1) with two common. Stem Cell Research, 2019 (41). ^#第一作者，*通訊作者

·?Jiangping He, Xiuling Fu, Meng Zhang, Fangfang He, Wenjuan Li, Mazid Md. Abdul, Jianguo Zhou, Li Sun, Chen Chang, Yuhao Li, He Liu, Kaixin Wu, Isaac A. Babarinde, Qiang Zhuang, Yuin-Han Loh, Jiekai Chen, Miguel A. Esteban and Andrew P. Hutchins. Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells. Nature Communications, 2019, 10(1), 34.?^#第一作者，*通訊作者

·?Mazid Md. Abdul, David P. Iba?ez, Ping Zhao, Hao Liu, Xiaofen Zhong, Yingying Li, Meng Zhang, Wenjuan Li, Yunpan Li, Carl Ward, Shuhan Chen, Dongye Wang, Baoming Qin, Miguel A. Esteban, Xiwei Wang*, Wenxia Fan*, Zhiwei Luo. Generation of an induced pluripotent stem cell line (GIBHi003-A) from a Parkinson's disease patient with mutant PINK1 (p. I368N). Stem Cell Research, 2019 (41). ^#第一作者，*通訊作者

·?Lulu Wang, Xueting Xu, Che Jiang, Gang Ma, Yinghua Huang, Hui Zhang, Yiwei Lai, Ming Wang, Tanveer Ahmed, Runxia Lin, Wenjing Guo, Zhiwei Luo, Wenjuan Li, Meng Zhang, Carl Ward, Minxian Qian, Baohua Liu, Miguel A. Esteban and Baoming Qin (2019) mTORC1-PGC1 axis regulates mitochondrial remodeling during reprogramming. The FEBS Journal. 2020 287(1):108-121.?^#第一作者，*通訊作者

·?Li Li, Quanjun Zhang, Huaqiang Yang, Qingjian Zou, Chengdan Lai, Fei Jiang, Ping Zhao, Zhiwei Luo, Jiayin Yang, Qian Chen, Yan Wang, Philip N. Newsome, Jon Frampton, Patrick H. Maxwell, Wenjuan Li, Shuhan Chen, Dongye Wang, Tak-Shing Siu, Sidney Tam, Hung-Fat Tse, Baoming Qin, Xichen Bao, Miguel A. Esteban* and Liangxue Lai*. Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1. The Journal of Biological Chemistry, 2017, (292) 11, 4755–4763. ^#第一作者，*通訊作者

·?Yan Xu#, Meng Zhang#, Wenjuan Li, Xihua Zhu, Xichen Bao, Baoming Qin, Andrew P. Hutchins* and Miguel A. Esteban*. Transcriptional Control of Somatic Cell Reprogramming. Trends in Cell Biology. 2016 26(4):272-288. ^#第一作者，*通訊作者

·?Longqi Liu^#, Yan Xu^#*, Minghui He^#, Meng Zhang, Fenggong Cui, Leina Lu, Mingze Yao,?Weihua Tian, Christina Benda, Qiang Zhuang, Zhijian Huang, Wenjuan Li, Xiangchun Li, Ping Zhao, Wenxia Fan, Zhiwei Luo, Yuan Li, Yasong Wu, Andrew P. Hutchins, Dongye Wang, Hung-Fat Tse, Axel Schambach, Jon Frampton, Baoming Qin, Xichen Bao, Hongjie Yao, Biliang Zhang, Hao Sun, Duanqing Pei, Huating Wang, Jun Wang, and Miguel A. Esteban*.?Transcriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming. Cell Stem Cell, 2014 15, 1-15. ^#第一作者，*通訊作者

專利

·?名稱：NCoR/SMRT蛋白復(fù)合體在調(diào)節(jié)細(xì)胞命運(yùn)轉(zhuǎn)變中的應(yīng)用

專利號(hào)：201610064508.7（已授權(quán)）

發(fā)明人：米格爾.埃斯特班；莊強(qiáng)；克里斯蒂娜.班達(dá)；安德魯.哈金斯；李文娟；許燕

·?名稱：建立和維持早期胚胎樣細(xì)胞的培養(yǎng)基和方法

專利號(hào)：202011256758.3（專利轉(zhuǎn)讓）

發(fā)明人：米格爾.A.埃斯特班，馬西德.M.阿卜杜爾，李文娟，駱志偉，卡爾.沃德，黎運(yùn)盼，賴毅維

·?名稱：Media and Methods for Establishing and Maintaining Early Embryo-Like Cells

專利號(hào)：PCT/CN2020/128091（專利轉(zhuǎn)讓）

發(fā)明人：米格爾.A.埃斯特班，馬西德.M.阿卜杜爾，李文娟，駱志偉，卡爾.沃德，黎運(yùn)盼，賴毅維

·?名稱：從畸胎瘤、類器官和擬胚體中產(chǎn)生人細(xì)胞和組織的培養(yǎng)基和方法

專利號(hào)：202211317527.8

發(fā)明人：米格爾.A.埃斯特班，李文娟，馬西德.M.阿卜杜爾，姜禹，賴毅維，駱志偉，李金秀

·?名稱：Media and Methods for Producing Human Cells and Tissues from Teratoma, Organoids and Embryoid Bodies

專利號(hào)：PCT/CN2022/081499

發(fā)明人：米格爾.A.埃斯特班，李文娟，馬西德.M.阿卜杜爾，姜禹，賴毅維，駱志偉，李金秀